Scientific References:

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1. Why Modern Medicine Keeps Overlooking Menopause. The New York Times, April 2021.
2. Woods, Nancy F. RN, PhD; Carr, Molly C. MD; Tao, Eunice Y. MD; Taylor, Heather J. BS; Mitchell, Ellen S. RN, PhD Increased urinary cortisol levels during the menopause transition, Menopause: March 2006 - Volume 13 - Issue 2.
3. Lee DY, Kim E, Choi MH. Technical and clinical aspects of cortisol as a biochemical marker of chronic stress. BMB Rep. 2015 Apr;48(4):209-16. doi: 10.5483
4. Joseph JJ, Golden SH. Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus. Ann N Y Acad Sci. 2017;1391(1):20-34. doi:10.1111/nyas.13217
5. Hannibal KE, Bishop MD. Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation. Phys Ther. 2014;94(12):1816-1825. doi:10.2522/ptj.20130597
6. Whitworth JA, Williamson PM, Mangos G, Kelly JJ. Cardiovascular consequences of cortisol excess. Vasc Health Risk Manag. 2005;1(4):291-299. doi:10.2147/vhrm.2005.1.4.291
7. McEwen BS. Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol. 2008;583(2-3):174-185. doi:10.1016/j.ejphar.2007.11.071
8. American Psychological Association (2019).Stress in America: Stress and Current Events. Stress in America™ Survey.
9. Women aged 45-54 suffer more stress and depression than all other age groups. Health and Safety Executive (HSE) Survey. 2014.
10. Sievert, L.L., Jaff, N. & Woods, N.F. Stress and midlife women's health. Women's Midlife Health 4, 4 (2018). doi.org/10.1186/s40695-018-0034-1
11. Sievert LL, Huicochea-Gómez L, Cahuich-Campos D, Ko'omoa-Lange DL, Brown DE. Stress and the menopausal transition in Campeche, Mexico. Womens Midlife Health. 2018 Jun 18;4:9. doi: 10.1186/s40695-018-0038-x. PMID: 30766719; PMCID: PMC6298015.
12. Kimberly A. Dienes, Nicholas A. Hazel, Constance L. Hammen. Cortisol secretion in depressed, and at-risk adults, Psychoneuroendocrinology, Volume 38, Issue 6, 2013. doi.org/10.1016/j.psyneuen.2012.09.019.
13. Qin, Dd., Rizak, J., Feng, Xl. et al. Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour. Sci Rep6, 30187 (2016). doi.org/10.1038/srep30187
14. Echouffo-Tcheugui JB, Conner SC, Himali JJ, Maillard P, DeCarli CS, Beiser AS, Vasan RS, Seshadri S. Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study. Neurology 2018.
15. Ouanes Sami, Popp Julius. High Cortisol and the Risk of Dementia and Alz Disease: A Review of the Literature. Frontiers in Aging Neuroscience. Vol 11. 2019.
16. Yale University. Stress May Cause Excess Abdominal Fat in Otherwise Slender Women. 2020.
17. Ohio State University. "Weighty issue: Stress and high-fat meals combine to slow metabolism in women." ScienceDaily. 14 July 2014.
18. William R. Lovallo, Noha H. Farag, Andrea S. Vincent, Terrie L. Thomas, Michael F. Wilson. Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and women. Pharmacology Biochemistry and Behavior. Volume 83, Issue 3, 2006.
19. Bennett JM, Rodrigues IM, Klein LC. Effects of caffeine and stress on biomarkers of cardiovascular disease in healthy men and women with a family history of hypertension. Stress Health. 2013 Dec;29(5):401-9. doi: 10.1002/smi.2486. Epub 2013 Mar 18.
20. Auddy, B. et al. 2008. Journal of the American Nutraceutical Association. 11(1):50-56.
21. Hintzpeter J, Stapelfeld C, Loerz C, Martin HJ, Maser E. Green tea and one of its constituents, Epigallocatechine-3-gallate, are potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. PLoS One. 2014;9(1):e84468. Published 2014 Jan 3. doi:10.1371/journal.pone.0084468
22. Hintzpeter J, Stapelfeld C, Loerz C, Martin HJ, Maser E. Green tea and one of its constituents, Epigallocatechine-3-gallate, are potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. PLoS One. 2014 Jan 3;9(1):e84468. doi: 10.1371/journal.pone.0084468.
23. Gilardini L, Pasqualinotto L, Di Pierro F, Risso P, Invitti C. Effects of Greenselect Phytosome® on weight maintenance after weight loss in obese women: a randomized placebo-controlled study. BMC Complement Altern Med. 2016 Jul 22;16:233. doi: 10.1186/s12906-016-1214-x.
24. Panossian A, Hambardzumyan M, Hovhanissyan A, Wikman G. The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol. Drug Target Insights. 2007;2:39-54.
25. Patricia L. Gerbarg, Richard P. Brown. Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator. Phytomedicine, Volume 23, Issue 7, 2016.
26. Bommer S, Klein P, Suter A. First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Adv Ther. 2011 Jun;28(6):490-500. doi: 10.1007/s12325-011-0027-z. Epub 2011 May 16.
27. Shakeri F, Taavoni S, Goushegir A, Haghani H. Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial. Climacteric. 2015;18(4):568-73. doi: 10.3109/13697137.2014.999660. Epub 2015 Feb 24.
28. Hidalgo LA, Chedraui PA, Morocho N, Ross S, San Miguel G. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol. 2005 Nov;21(5):257-64. doi: 10.1080/09513590500361192.
29. Shams T, Setia MS, Hemmings R, et al. Efficacy of black cohosh-containing preparations on menopausal symptoms: a meta-analysis. 2010.
30. Jiang K, Jin Y, Huang L, Feng S, Hou X, Du B, Zheng J, Li L. Black cohosh improves objective sleep in postmenopausal women with sleep disturbance. Climacteric. 2015;18(4):559-67. doi: 10.3109/13697137.2015.1042450. Epub 2015 May 22.
31. Vitex agnus-castus Extracts for Female Reproductive Disorders: A Systematic Review of Clinical Trials. Planta Med 2013; 79(07): 562-575. DOI: 10.1055/s-0032-1327831
32. Chopin Lucks B. Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154]. Complement Ther Nurs Midwifery. 2003 Aug;9(3):157-60. doi: 10.1016/S1353-6117(03)00020-9.
33. Van Die MD, Burger HG, Teede HJ, Bone KM. Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints. J Altern Complement Med. 2009 Aug;15(8):853-62. doi: 10.1089/acm.2008.0447.
34. The Immense Burden of Menopausal Symptoms. MGH Center for Women's Mental Health, May, 2015.